Services

D2M is able to offer translational expertise from which a range of strategic partnerships and value-added services can be developed.

D2M Profile
  • High quality service in a cost effective manner
  • Excellent communication with client
  • Project management methodologies always employed
  • Experienced personnel with delivery focus
  • Access to leading expertise in wide range of therapeutic areas
  • Commitment to deliver on projects
Medicinal Chemistry Consultancy

The D2M team undertake reviews and appraisals of the need for medicinal chemistry in its widest definition on a project-by-project basis. Thus, in some cases the appropriate next steps for a biotech discovery group or SME may be chemical synthesis, some form of structural biology, computational chemistry or bioinformatics analysis. In others it may be development of a means to a more robust and useful assay for lead discovery through to advice on formulation or drug delivery modalities.

Computational
  • Virtual screening
  • Cheminformatics/database
  • Structure-based design
  • De novo design
  • Homology modelling
  • Pharmacophore modelling
  • Protein-ligand docking/modelling
  • Hit identification
  • Identification of hot spots using computational alanine scanning (via MMPBSA)
  • Lead optimisation
  • Ab initio calculations
  • Molecular dynamics simulations
  • QM/MM simulations
  • Free energy calculations
  • QSAR
  • Molecular modelling training
Separation
  • HPLC, Liquid Chromatography
    • Flexible access
    • Analytical, Semi-prep, Preparative
  • Protein Isolation and Characterisation
    • FPLC
    • Electrophoresis
Characterisation
  • NMR, Nuclear Magnetic Resonance
  • 300, 400, 500 MHz Bruker
    • 300 MHz- Open Access
    • 400, 500 MHz- Service operated
    • Nuclei: 1H, 13C, 19F, 31P
    • 1D experiments, 1H, 13C, DEPT
    • 2D experiments, 1H-1H COSY, 1H-13C HMQC/ HMBC, NOESY, ROESY etc
  • FTIR, Infrared spectroscopy
    • Jasco FT-4100 spectrometer with additional Diamond ATR
    • Spectral library for compound identification
  • UV/Vis
    • Cary 4000 spectrometer and Tecan Safire 96 well plate reader
  • Fluorescence
    • Cary Eclipse spectrometer, Fluorescence Lifetime and Tecan Safire 96 well plate reader
Synthesis
  • Synthetic Organic Chemistry
  • Conventional synthesis (1 mg - 200 g scale)
  • Parallel 12 place reaction station and workup facilities (10 mg – 10 g scale)
  • Microwave synthesis (200 μL – 20 mL scale)
  • Medicinal chemistry – reactions performed up to a 160 ml range
  • Parallel – up to 24 reactions performed simultaneously
  • Combinatorial – Process multiple microwell plates for rapidly producing large libraries of compounds
  • Scale-up – large scale up to 4 L (using batch and flow reactors)

D2M can offer excellence in:

  • Medicinal Chemistry Panel Consultancy (design and feasibility)
  • Chemistry
    • Synthetic Chemistry (pilot scale to scale up)
    • Library design & synthesis (feasibility and preferences)
  • Computational Chemistry (a whole range of services, part of our usp)
  • Analytical/Biophysical ( NMR, Mass Spec, Fluorescence, Correlation spectroscopy, etc.)
  • IP Status (literature searching and assessment )
  • Biology/biochemistry
    • Cell and molecular aspects
    • New tools (early stage to HTS)
    • Assay development & validation
    • Target validation
  • Metabolism/Toxicity studies (specialising in P450, protein binding,)
  • Pharmaceutical input (formulation, stability etc)
  • Preclinical (access to real models)
  • Diagnostics (tools and services)
  • Strategic analysis – business plans or project proposals by recognised experts
  • Grant applications, research funding & POC proposals